Unbalanced population sampling and STRUCTURE

Posted on 5 January, 2017 by Arun Sethuraman on
“The utility and intuition offered by the program STRUCTURE, and more generally, the ‘admixture’ model of Pritchard et al. (2000) are unquestioned – with tens of thousands of citations, it retains its lead among the most popular population genetics software. However, much like any method, STRUCTURE comes with its caveats, which recent works have pointed to using simulations and meta-analyses (see here, and also the studies of Gilbert et al. 2012, Evanno et al. 2005, Puechmaille 2016). In a recent manuscript, Wang (2016) quantifies the effect of unbalanced sampling and specification of ancestry priors on STRUCTURE’s estimates.” (…)

Terry via Celine

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